Big Problems from Little Kidneys

From little things big things grow: . . .

A little pRB can lead to big problems.

SUMMARY Germline deletion of RB1, the gene encoding the retinoblastoma tumor-suppressor protein pRB, predisposes to eye tumor formation upon loss of the remaining wild-type allele. Many functions affecting cell-cycle control, cell-cycle exit, and numerous other processes involved in the transformed phenotype have been ascribed to pRB, and deregulation of these processes is generally thought to ...

From Little Bangs to the Big Bang

The ‘Little Bangs’ made in particle collider experiments reproduce the conditions in the Big Bang when the age of the Universe was a fraction of a second. It is thought that matter was generated, the structures in the Universe were formed and cold dark matter froze out during this very early epoch when the equation of state of the Universe was dominated by the quark-gluon plasma (QGP). Future L...

Big Corrections from a Little Higgs

We calculate the tree-level expressions for the electroweak precision observables in the SU(5)/SO(5) littlest Higgs model. The source for these corrections are the exchange of heavy gauge bosons and a triplet Higgs VEV. Weak isospin violating contributions are present because there is no custodial SU(2) global symmetry. The bulk of these weak isospin violating corrections arise from heavy gauge...

Big brains, little bodies.

www.sciencemag.org SCIENCE VOL 338 14 DECEMBER 2012 1389 COVER Arachnoscelis magnifi ca, a predaceous katydid (Orthoptera: Tettigoniidae), on a leaf in the San Lorenzo forest of Panama. This attractive insect is but one of the ~25,000 arthropod species likely to live in this 6000-hectare forest, confi rming the formidable diversity of arthropods, which appears to be 300 times that of mammals in...